|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:TNF-alpha
gptkb:tumor_necrosis_factor_ligand_superfamily_member_2
gptkb:cachectin
|
|
gptkbp:disulfideBond
|
yes
|
|
gptkbp:EC_number
|
none
|
|
gptkbp:function
|
immune response
inflammatory response
cytokine activity
induction of apoptotic cell death
|
|
gptkbp:gene
|
gptkb:TNF
|
|
gptkbp:GOProcess
|
GO:0006954
|
|
gptkbp:hasComponent
|
gptkb:GO:0005615
|
|
gptkbp:hasDiseaseAssociation
|
gptkb:Crohn's_disease
ulcerative colitis
psoriasis
septic shock
rheumatoid arthritis
ankylosing spondylitis
|
|
gptkbp:hasGOFunction
|
gptkb:GO:0005125
|
|
gptkbp:hasPfamDomain
|
PF00229
|
|
gptkbp:hasReceptor
|
gptkb:TNFRSF1A
gptkb:TNFRSF1B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P05362
|
|
gptkbp:InterPro
|
IPR006052
|
|
gptkbp:length
|
233 amino acids
|
|
gptkbp:locatedOnChromosome
|
6
6p21.33
|
|
gptkbp:molecularWeight
|
25.6 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
P06804
P16599
Q544R4
|
|
gptkbp:pathway
|
KEGG:hsa04060
KEGG:hsa04620
KEGG:hsa04668
Reactome:R-HSA-168256
Reactome:R-HSA-5669034
|
|
gptkbp:PDB
|
gptkb:1TNF
gptkb:2TNF
gptkb:3TNF
|
|
gptkbp:postTranslationalModification
|
phosphorylation
cleavage
glycosylation
|
|
gptkbp:reviewedBy
|
yes
|
|
gptkbp:signalPeptide
|
yes
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
secreted
|
|
gptkbp:targetOfDrug
|
yes
|
|
gptkbp:UniProt_entry_name
|
gptkb:TNFA_HUMAN
gptkb:Tumor_necrosis_factor
|
|
gptkbp:UniProtID
|
gptkb:P05362
|
|
gptkbp:bfsParent
|
gptkb:ICAM-1
gptkb:ICAM1
|
|
gptkbp:bfsLayer
|
7
|