Tumor Necrosis Factor alpha

URI: https://gptkb.org/entity/Tumor_Necrosis_Factor_alpha
GPTKB entity
Statements (36)
Predicate Object
gptkbp:instanceOf cytokine
gptkbp:abbreviation gptkb:TNF-α
gptkbp:associatedWith gptkb:Crohn's_disease
psoriasis
septic shock
rheumatoid arthritis
gptkbp:category signaling molecule
immune system protein
pro-inflammatory cytokine
gptkbp:discoveredBy gptkb:Lloyd_J._Old
gptkbp:discoveredIn 1975
gptkbp:encodedBy gptkb:TNF_gene
gptkbp:function apoptosis induction
induction of inflammation
inhibition of tumorigenesis
inhibition of viral replication
regulation of immune cells
gptkbp:gene gptkb:TNF
https://www.w3.org/2000/01/rdf-schema#label Tumor Necrosis Factor alpha
gptkbp:locatedOnChromosome gptkb:6p21.3
gptkbp:molecularWeight 17 kDa (monomer)
gptkbp:orthologIn Tumor Necrosis Factor beta
gptkbp:producedBy gptkb:natural_killer_cells
gptkb:T_cells
macrophages
gptkbp:recipient gptkb:TNFR1
gptkb:TNFR2
gptkbp:structure homotrimer
gptkbp:target gptkb:etanercept
gptkb:infliximab
gptkb:adalimumab
gptkbp:UniProtID gptkb:P01375
gptkbp:bfsParent gptkb:TNF-alpha
gptkb:1TNF
gptkb:TNF-α
gptkbp:bfsLayer 7