Tumor Necrosis Factor alpha

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cytokine
gptkbp:abbreviation	gptkb:TNF-α
gptkbp:associatedWith	gptkb:Crohn's_disease psoriasis septic shock rheumatoid arthritis
gptkbp:category	gptkb:signaling_molecule immune system protein pro-inflammatory cytokine
gptkbp:discoveredBy	gptkb:Lloyd_J._Old
gptkbp:discoveredIn	1975
gptkbp:encodedBy	gptkb:TNF_gene
gptkbp:function	apoptosis induction induction of inflammation inhibition of tumorigenesis inhibition of viral replication regulation of immune cells
gptkbp:gene	gptkb:TNF
gptkbp:locatedOnChromosome	gptkb:6p21.3
gptkbp:molecularWeight	17 kDa (monomer)
gptkbp:orthologIn	Tumor Necrosis Factor beta
gptkbp:producedBy	gptkb:natural_killer_cells gptkb:T_cells macrophages
gptkbp:recipient	gptkb:TNFR1 gptkb:TNFR2
gptkbp:structure	homotrimer
gptkbp:target	gptkb:etanercept gptkb:infliximab gptkb:adalimumab
gptkbp:UniProtID	gptkb:P01375
gptkbp:bfsParent	gptkb:TNF-alpha
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Tumor Necrosis Factor alpha