tumor necrosis factor-alpha

URI: https://gptkb.org/entity/tumor_necrosis_factor-alpha
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf cytokine
gptkbp:abbreviation gptkb:TNF-α
gptkbp:associatedWith gptkb:Crohn's_disease
psoriasis
septic shock
rheumatoid arthritis
gptkbp:category immune system protein
signaling protein
pro-inflammatory cytokine
gptkbp:discoveredBy gptkb:Lloyd_J._Old
gptkbp:discoveredIn 1975
gptkbp:encodedBy gptkb:TNF_gene
gptkbp:function immune system regulation
apoptosis inducer
inflammation mediator
gptkbp:gene gptkb:TNF
https://www.w3.org/2000/01/rdf-schema#label tumor necrosis factor-alpha
gptkbp:inducedBy fever
cachexia
cell death
gptkbp:inhibitedBy tumorigenesis
viral replication
gptkbp:locatedOnChromosome gptkb:6p21.3
gptkbp:molecularWeight 17 kDa (monomer)
gptkbp:orthologIn gptkb:lymphotoxin-alpha
tumor necrosis factor-beta
gptkbp:producedBy gptkb:natural_killer_cells
gptkb:T_cells
macrophages
gptkbp:promotion acute phase reaction
gptkbp:recipient gptkb:TNFR1
gptkb:TNFR2
gptkbp:regulates gptkb:NF-κB_pathway
apoptosis
cell proliferation
cell survival
differentiation
inflammatory response
cytokine production
immune cell activation
leukocyte recruitment
endothelial cell function
gptkbp:structure trimer
gptkbp:target gptkb:etanercept
gptkb:infliximab
gptkb:adalimumab
gptkbp:targetOfDrug autoimmune diseases
inflammatory diseases
gptkbp:UniProtID gptkb:P01375
gptkbp:bfsParent gptkb:CD4+_T_cells
gptkb:CD8+_T_cell
gptkbp:bfsLayer 6