Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
fibrosis
cancer progression |
| gptkbp:form |
heteromeric complexes with TGF-beta receptor type II
|
| gptkbp:function |
transduces signals from TGF-beta ligands
|
| gptkbp:has_role |
gptkb:embryonic_development
|
| https://www.w3.org/2000/01/rdf-schema#label |
TGF-beta receptor type I
|
| gptkbp:initiated_by |
gptkb:TGF-beta_receptor_type_II
gptkb:TGF-beta1 gptkb:TGF-beta2 gptkb:TGF-beta3 certain small molecules |
| gptkbp:interacts_with |
TGF-beta ligands
|
| gptkbp:involved_in |
apoptosis
immune response regulation cell growth regulation |
| gptkbp:is_associated_with |
autoimmune diseases
cardiovascular diseases |
| gptkbp:is_expressed_in |
various tissues
|
| gptkbp:is_involved_in |
gptkb:neurodegenerative_diseases
regulation of apoptosis cell cycle regulation cell differentiation signal transduction wound healing regulation of gene expression angiogenesis chronic inflammation tissue repair cell migration extracellular matrix production metastasis stem cell maintenance metabolic regulation tumor microenvironment modulation epithelial-mesenchymal transition cellular responses to stress tissue fibrosis regulation of metabolic pathways immune evasion in tumors regulation of cell adhesion regulation of cell signaling pathways regulation of cell surface receptors regulation of cellular apoptosis regulation of cellular differentiation regulation of cellular homeostasis regulation of cellular metabolism regulation of cellular proliferation regulation of cytokine production regulation of growth factors regulation of ion channels regulation of transcription factors |
| gptkbp:is_part_of |
TGF-beta signaling pathway
|
| gptkbp:is_regulated_by |
gptkb:SARA_protein
gptkb:SMAD_proteins gptkb:TRAF_proteins |
| gptkbp:is_targeted_at |
therapeutic antibodies
|
| gptkbp:location |
cell membrane
|
| gptkbp:promoter |
gptkb:TGFBR1
|
| gptkbp:weight |
approximately 55 k Da
|
| gptkbp:bfsParent |
gptkb:TGF-beta
|
| gptkbp:bfsLayer |
7
|