Transforming Growth Factor beta

URI: https://gptkb.org/entity/Transforming_Growth_Factor_beta
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:TGF-β
gptkbp:category gptkb:cytokine
gptkb:growth_factor
gptkb:signaling_molecule
gptkbp:discoveredBy gptkb:Anita_B._Roberts
gptkb:Michael_B._Sporn
gptkbp:discoveredIn 1983
gptkbp:family Transforming Growth Factor beta family
gptkbp:foundIn humans
mammals
vertebrates
gptkbp:function regulation of apoptosis
regulation of cell differentiation
regulation of cell growth
regulation of immune system
gptkbp:gene gptkb:TGFB1
gptkb:TGFB2
gptkb:TGFB3
gptkbp:inhibitedBy epithelial cell growth
gptkbp:involvedIn epithelial-mesenchymal transition
tissue repair
immune suppression
gptkbp:modulatedBy angiogenesis
cell migration
inflammation
immune tolerance
gptkbp:pathway SMAD signaling pathway
gptkbp:promotion collagen synthesis
fibroblast proliferation
gptkbp:recipient gptkb:TGF-beta_receptor_type_I
gptkb:TGF-beta_receptor_type_II
gptkb:TGF-beta_receptor_type_III
gptkbp:regulates cell proliferation
immune cell function
extracellular matrix production
gptkbp:relatedTo Activins
Bone Morphogenetic Proteins
Myostatin
Nodal proteins
gptkbp:role gptkb:cancer
gptkb:cardiovascular_disease
wound healing
autoimmune diseases
embryogenesis
fibrosis
gptkbp:structure dimeric protein
gptkbp:bfsParent gptkb:TGF-beta_signaling_pathway
gptkb:TGF-beta
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Transforming Growth Factor beta