Transforming Growth Factor beta
GPTKB entity
Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:TGF-β
|
| gptkbp:category |
growth factor
signaling molecule cytokine |
| gptkbp:discoveredBy |
gptkb:Anita_B._Roberts
gptkb:Michael_B._Sporn |
| gptkbp:discoveredIn |
1983
|
| gptkbp:family |
Transforming Growth Factor beta family
|
| gptkbp:foundIn |
humans
mammals vertebrates |
| gptkbp:function |
regulation of apoptosis
regulation of cell differentiation regulation of cell growth regulation of immune system |
| gptkbp:gene |
gptkb:TGFB1
gptkb:TGFB2 gptkb:TGFB3 |
| https://www.w3.org/2000/01/rdf-schema#label |
Transforming Growth Factor beta
|
| gptkbp:inhibitedBy |
epithelial cell growth
|
| gptkbp:involvedIn |
epithelial-mesenchymal transition
tissue repair immune suppression |
| gptkbp:modulatedBy |
angiogenesis
cell migration inflammation immune tolerance |
| gptkbp:pathway |
SMAD signaling pathway
|
| gptkbp:promotion |
collagen synthesis
fibroblast proliferation |
| gptkbp:recipient |
gptkb:TGF-beta_receptor_type_I
gptkb:TGF-beta_receptor_type_II gptkb:TGF-beta_receptor_type_III |
| gptkbp:regulates |
cell proliferation
immune cell function extracellular matrix production |
| gptkbp:relatedTo |
Activins
Bone Morphogenetic Proteins Myostatin Nodal proteins |
| gptkbp:role |
gptkb:cancer
gptkb:cardiovascular_disease wound healing autoimmune diseases embryogenesis fibrosis |
| gptkbp:structure |
dimeric protein
|
| gptkbp:bfsParent |
gptkb:TGF-beta_signaling_pathway
gptkb:TGF-beta |
| gptkbp:bfsLayer |
7
|