Statements (67)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
TGF-beta signaling pathway
|
| gptkbp:clinical_trial |
involved in fibrosis
|
| gptkbp:dimensions |
forms a complex with TGF-beta receptor type I
|
| gptkbp:established |
can be blocked by specific antibodies
can be targeted for cancer therapy |
| gptkbp:function |
binds to TGF-beta ligands
|
| gptkbp:genetic_diversity |
associated with various cancers
|
| https://www.w3.org/2000/01/rdf-schema#label |
TGF-beta receptor type II
|
| gptkbp:interacts_with |
gptkb:TGF-beta_receptor_type_I
|
| gptkbp:is_a_route_for |
involved in cardiovascular diseases
involved in tissue repair affects reproductive health activates SMAD proteins affects angiogenesis affects cardiac function affects cell migration affects chronic inflammatory diseases affects joint diseases affects metabolic disorders affects metabolic processes affects neurodevelopmental disorders influences aging processes influences autoimmune diseases influences bone metabolism influences cellular senescence influences muscle atrophy influences muscle regeneration influences reproductive aging influences stem cell behavior influences tumor microenvironment involved in chronic kidney disease involved in fibrosis progression involved in liver fibrosis involved in metabolic adaptation involved in neurodegeneration involved in respiratory diseases involved in skin disorders modulates apoptosis signaling modulates immune cell function regulates bone remodeling regulates cell cycle progression regulates extracellular matrix production regulates hematopoiesis regulates inflammation regulates metabolic syndrome regulates neuroinflammation regulates pancreatic function regulates vascular remodeling involved in epithelial-mesenchymal transition (EMT) |
| gptkbp:is_represented_in |
found in many tissues
|
| gptkbp:location |
cell membrane
|
| gptkbp:products |
gptkb:TGF-beta1
gptkb:TGF-beta2 gptkb:TGF-beta3 |
| gptkbp:promoter |
TGFB R2
|
| gptkbp:research |
target for drug development
|
| gptkbp:role |
regulates cell growth
involved in immune response in apoptosis in cell differentiation in embryonic development in wound healing |
| gptkbp:transponders |
activates downstream signaling pathways
|
| gptkbp:type |
gptkb:protein
|
| gptkbp:bfsParent |
gptkb:TGF-beta
|
| gptkbp:bfsLayer |
7
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