TGF-beta receptor type II

URI: https://gptkb.org/entity/TGF-beta_receptor_type_II

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:TGFBR2 Transforming growth factor beta receptor II
gptkbp:associatedWith	gptkb:hereditary_nonpolyposis_colorectal_cancer gptkb:Marfan_syndrome
gptkbp:binds	TGF-beta ligand
gptkbp:domain	extracellular domain transmembrane domain cytoplasmic kinase domain
gptkbp:encodedBy	gptkb:TGFBR2_gene
gptkbp:formsComplexWith	gptkb:TGF-beta_receptor_type_I
gptkbp:function	gptkb:GO:0005024 serine/threonine kinase activity
gptkbp:involvedIn	gptkb:TGF-beta_signaling_pathway
gptkbp:locatedIn	gptkb:cell_membrane
gptkbp:locatedOnChromosome	3p24.1
gptkbp:molecularWeight	70 kDa
gptkbp:mutationAssociatedWith	gptkb:Loeys-Dietz_syndrome gptkb:cancer
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:PDB	5E8V
gptkbp:phosphorylates	gptkb:TGF-beta_receptor_type_I
gptkbp:RefSeq	NP_003233.3
gptkbp:UniProtID	P37173
gptkbp:bfsParent	gptkb:TGF-beta
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	TGF-beta receptor type II