TGF-beta receptor type II

URI: https://gptkb.org/entity/TGF-beta_receptor_type_II
GPTKB entity
Statements (30)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeName gptkb:TGFBR2
Transforming growth factor beta receptor II
gptkbp:associatedWith gptkb:hereditary_nonpolyposis_colorectal_cancer
gptkb:Marfan_syndrome
gptkbp:binds TGF-beta ligand
gptkbp:domain extracellular domain
transmembrane domain
cytoplasmic kinase domain
gptkbp:encodedBy gptkb:TGFBR2_gene
gptkbp:formsComplexWith gptkb:TGF-beta_receptor_type_I
gptkbp:function gptkb:GO:0005024
serine/threonine kinase activity
https://www.w3.org/2000/01/rdf-schema#label TGF-beta receptor type II
gptkbp:involvedIn gptkb:TGF-beta_signaling_pathway
gptkbp:locatedIn gptkb:cell_membrane
gptkbp:locatedOnChromosome 3p24.1
gptkbp:molecularWeight 70 kDa
gptkbp:mutationAssociatedWith gptkb:Loeys-Dietz_syndrome
gptkb:cancer
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 5E8V
gptkbp:phosphorylates gptkb:TGF-beta_receptor_type_I
gptkbp:RefSeq NP_003233.3
gptkbp:UniProtID P37173
gptkbp:bfsParent gptkb:TGF-beta_receptor
gptkb:TGFBR2
gptkb:TGF-beta
gptkbp:bfsLayer 7