Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:CED
gptkb:TGFB DPD1 TGF-beta-1 |
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases fibrosis |
| gptkbp:biologicalProcess |
signal transduction
growth factor activity extracellular matrix organization regulation of immune system process cellular response to stimulus |
| gptkbp:cellularComponent |
extracellular region
secreted |
| gptkbp:discoveredBy |
gptkb:Anita_B._Roberts
gptkb:Michael_B._Sporn |
| gptkbp:discoveredIn |
1983
|
| gptkbp:encodes |
transforming growth factor beta-1 protein
|
| gptkbp:Entrez_Gene_ID |
7040
ENSG00000105329 |
| gptkbp:expressedIn |
many tissues
|
| gptkbp:fullName |
transforming growth factor beta 1
|
| gptkbp:function |
regulation of cell differentiation
regulation of cell growth cytokine activity extracellular matrix production immune system modulation |
| gptkbp:hasClinicalTest |
genetic testing for Camurati-Engelmann disease
|
| gptkbp:HGNC_ID |
HGNC:11766
|
| https://www.w3.org/2000/01/rdf-schema#label |
TGFB1
|
| gptkbp:interactsWith |
gptkb:SMAD2
gptkb:SMAD3 gptkb:ENG gptkb:TGFBR2 gptkb:TGFBR1 gptkb:SMAD4 LTBP1 |
| gptkbp:locatedOnChromosome |
19
19q13.2 |
| gptkbp:mutationAssociatedWith |
inflammatory diseases
Camurati-Engelmann disease |
| gptkbp:OMIM |
190180
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
Mus musculus (mouse)
Danio rerio (zebrafish) Rattus norvegicus (rat) |
| gptkbp:pathway |
gptkb:TGF-beta_signaling_pathway
|
| gptkbp:PDB |
3KFD
1KLA 1TFG |
| gptkbp:product |
TGF-beta 1
|
| gptkbp:proteinFamily |
gptkb:TGF-beta_superfamily
|
| gptkbp:regulates |
apoptosis
cell proliferation wound healing immune response |
| gptkbp:UniProtID |
P01137
|
| gptkbp:bfsParent |
gptkb:TGF-beta
|
| gptkbp:bfsLayer |
7
|