Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:A2M
gptkb:C3_and_C4_binding_protein gptkb:alpha-2-macroglobulin |
| gptkbp:discoveredBy |
gptkb:Heinrich_Schultze
|
| gptkbp:discoveredIn |
1950s
|
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:function |
protease inhibitor
inhibits thrombin inhibits plasmin inhibits trypsin |
| gptkbp:gene |
gptkb:A2M
|
| https://www.w3.org/2000/01/rdf-schema#label |
alpha2-macroglobulin
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_12p13.31
|
| gptkbp:location |
gptkb:plasma
|
| gptkbp:molecularWeight |
720 kDa (tetramer)
|
| gptkbp:OMIM |
103950
|
| gptkbp:PDB |
4ACQ
|
| gptkbp:presentIn |
blood plasma
|
| gptkbp:role_in_immunity |
binds growth factors
binds cytokines broad-spectrum protease inhibitor modulates cytokine activity removes proteases from circulation |
| gptkbp:significance |
elevated in liver disease
involved in Alzheimer’s disease marker for nephrotic syndrome |
| gptkbp:structure |
tetramer
|
| gptkbp:UniProtID |
P01023
|
| gptkbp:bfsParent |
gptkb:TGF-beta
|
| gptkbp:bfsLayer |
7
|