Transforming Growth Factor superfamily
GPTKB entity
Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
TGF superfamily
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:foundIn |
animals
humans |
| gptkbp:function |
regulation of apoptosis
regulation of cell differentiation regulation of cell growth regulation of embryonic development regulation of immune system |
| gptkbp:GO_term |
GO:0005159
|
| https://www.w3.org/2000/01/rdf-schema#label |
Transforming Growth Factor superfamily
|
| gptkbp:includes |
Activins
Nodal proteins Bone Morphogenetic Proteins (BMPs) Growth Differentiation Factors (GDFs) Inhibins Müllerian Inhibiting Substance (MIS) Transforming Growth Factor beta (TGF-β) |
| gptkbp:ligand |
gptkb:GDF5
gptkb:Activin_A gptkb:BMP2 gptkb:BMP4 gptkb:BMP7 gptkb:Inhibin_A gptkb:Nodal TGF-β1 TGF-β3 TGF-β2 Müllerian Inhibiting Substance |
| gptkbp:memberOf |
cytokine family
|
| gptkbp:mutationAssociatedWith |
gptkb:fibrodysplasia_ossificans_progressiva
gptkb:hereditary_hemorrhagic_telangiectasia gptkb:Marfan_syndrome |
| gptkbp:pathway |
gptkb:SMAD_pathway
|
| gptkbp:recipient |
serine/threonine kinase receptors
|
| gptkbp:regulates |
wound healing
angiogenesis organogenesis immune cell function stem cell differentiation extracellular matrix production |
| gptkbp:relatedTo |
gptkb:cancer
developmental disorders fibrosis |
| gptkbp:subfamily |
Activin subfamily
BMP subfamily GDF subfamily MIS subfamily Nodal subfamily TGF-β subfamily |
| gptkbp:bfsParent |
gptkb:TGF-beta
|
| gptkbp:bfsLayer |
7
|