Statements (36)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
gptkb:BMP_receptors
TGF-beta receptors |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
developmental disorders fibrosis |
| gptkbp:firstDescribed |
1990s
|
| https://www.w3.org/2000/01/rdf-schema#label |
SMAD pathway
|
| gptkbp:involves |
gptkb:SMAD2
gptkb:SMAD3 gptkb:SMAD1 gptkb:SMAD5 gptkb:SMAD6 gptkb:SMAD7 gptkb:SMAD8 gptkb:SMAD4 gptkb:SMAD_proteins TGF-beta signaling BMP signaling nuclear translocation of SMAD proteins phosphorylation of SMAD proteins |
| gptkbp:medium |
signal transduction
|
| gptkbp:namedAfter |
gptkb:SMAD_proteins
|
| gptkbp:negatively_regulated_by |
gptkb:SMAD6
gptkb:SMAD7 |
| gptkbp:occurredIn |
eukaryotic cells
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation embryonic development gene expression |
| gptkbp:bfsParent |
gptkb:Growth_Differentiation_Factor_2
gptkb:TGF-beta_superfamily gptkb:bone_morphogenetic_proteins gptkb:TGF-beta |
| gptkbp:bfsLayer |
7
|