Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:SPRY2
hSPRY2 |
| gptkbp:associatedWith |
gptkb:cancer
cell differentiation cell growth |
| gptkbp:discoveredBy |
1999
|
| gptkbp:encodes |
Sprouty protein homolog 2
|
| gptkbp:Entrez_Gene_ID |
ENSG00000136158
10253 |
| gptkbp:expressedIn |
various tissues
ubiquitous high in kidney high in brain high in placenta high in lung |
| gptkbp:fullName |
Sprouty RTK signaling antagonist 2
|
| gptkbp:function |
regulation of receptor tyrosine kinase signaling
negative regulation of MAPK/ERK pathway |
| gptkbp:HGNC_ID |
11270
|
| https://www.w3.org/2000/01/rdf-schema#label |
SPRY2 gene
|
| gptkbp:interactsWith |
gptkb:EGFR
gptkb:SHC1 gptkb:FGFR1 gptkb:PI3K gptkb:GRB2 gptkb:RAF1 gptkb:SOS1 gptkb:c-Cbl |
| gptkbp:length |
315 amino acids
|
| gptkbp:locatedOnChromosome |
13
13q31.1 |
| gptkbp:mutationAssociatedWith |
tumorigenesis
|
| gptkbp:OMIM |
602466
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Spry2
|
| gptkbp:pathway |
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway RTK signaling pathway |
| gptkbp:proteinFamily |
Cysteine-rich domain
Sprouty domain |
| gptkbp:regulates |
EGF signaling
FGF signaling VEGF signaling post-translationally modified by phosphorylation transcriptionally regulated by growth factors |
| gptkbp:relatedDisorders |
gptkb:cancer
gptkb:glioblastoma colorectal cancer prostate cancer |
| gptkbp:significance |
implicated in cancer progression
potential biomarker for cancer potential tumor suppressor |
| gptkbp:UniProtID |
O43597
|
| gptkbp:bfsParent |
gptkb:Sprouty2
|
| gptkbp:bfsLayer |
7
|