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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
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gptkb:Ras_superfamily
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gptkbp:biologicalProcess
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GTP binding
GTPase activity
GDP binding
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gptkbp:contains
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gptkb:MRAS
gptkb:RALA
gptkb:RALB
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
gptkb:RHEB
gptkb:RIN1
gptkb:RIT1
gptkb:RIT2
gptkb:RRAS
gptkb:RRAS2
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
gptkb:RAN
gptkb:ARF_proteins
gptkb:RAB_proteins
gptkb:RAP_proteins
gptkb:RHO_proteins
gptkb:RIN2
gptkb:RIN3
RERG
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gptkbp:discoveredBy
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gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
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gptkbp:firstDescribed
|
1982
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gptkbp:foundIn
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animals
humans
eukaryotes
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gptkbp:function
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signal transduction
regulation of cell differentiation
regulation of cell proliferation
regulation of cell survival
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gptkbp:GO_term
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GO:0003924 (GTPase activity)
GO:0005525 (GTP binding)
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|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS protein family
|
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gptkbp:locatedOnChromosome
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gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
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gptkbp:mutationAssociatedWith
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gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
various developmental disorders
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gptkbp:namedAfter
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gptkb:rat_sarcoma_virus
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gptkbp:OMIM
|
190020
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gptkbp:regulates
|
gptkb:GDIs_(guanine_nucleotide_dissociation_inhibitors)
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:RalGEF_pathway
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
cell cycle progression
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gptkbp:relatedTo
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oncogenes
signal transduction proteins
|
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gptkbp:structure
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gptkb:P-loop_NTPase_fold
small molecule
|
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gptkbp:UniProtID
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gptkb:P-loop_GTPases
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gptkbp:bfsParent
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gptkb:NRAS_protein
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gptkbp:bfsLayer
|
6
|