|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:discoveredBy
|
Takai et al.
|
|
gptkbp:example
|
gptkb:RAB5
RAB1
RAB11
RAB7
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:function
|
regulation of vesicle trafficking
|
|
gptkbp:GO_term
|
GO:0005525 (GTP binding)
GO:0006886 (intracellular protein transport)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAB proteins
|
|
gptkbp:interactsWith
|
effector proteins
|
|
gptkbp:locale
|
membranes
cytosol
|
|
gptkbp:member
|
gptkb:Ras_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Charcot-Marie-Tooth_disease
gptkb:Griscelli_syndrome
|
|
gptkbp:numberOfMembers
|
over 60 in humans
|
|
gptkbp:orthologIn
|
gptkb:yeast
animals
plants
|
|
gptkbp:postTranslationalModification
|
prenylation
|
|
gptkbp:regulates
|
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
gptkb:GDIs_(GDP_dissociation_inhibitors)
autophagy
endocytosis
exocytosis
membrane trafficking
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkb:Annual_Review_of_Cell_and_Developmental_Biology
|
|
gptkbp:structure
|
G domain
|
|
gptkbp:subclassOf
|
small molecule
|
|
gptkbp:bfsParent
|
gptkb:RAS_protein_family
|
|
gptkbp:bfsLayer
|
7
|