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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:coat_protein_complex_I_(COPI)
gptkb:phospholipase_D
clathrin adaptor proteins
coat protein complex II (COPII)
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:database
|
Gene Ontology: GO:0005525
Pfam: PF00025
UniProt: P84077 (ARF1)
|
|
gptkbp:discoveredBy
|
gptkb:Joel_Moss
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
ARF genes
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:fullName
|
ADP-ribosylation factor proteins
|
|
gptkbp:function
|
regulate actin cytoskeleton dynamics
regulate vesicle trafficking
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ARF proteins
|
|
gptkbp:involvedIn
|
signal transduction
lipid metabolism
cell division
cell migration
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
Golgi membranes
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
gptkb:small_GTPase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurological disorders
|
|
gptkbp:orthologIn
|
gptkb:yeast
animals
plants
|
|
gptkbp:regulates
|
endocytosis
exocytosis
membrane traffic
regulated by GEFs (guanine nucleotide exchange factors)
Golgi apparatus function
regulated by GAPs (GTPase-activating proteins)
|
|
gptkbp:relatedTo
|
gptkb:ARL_proteins
gptkb:SAR_proteins
|
|
gptkbp:structure
|
contain GTP-binding domain
|
|
gptkbp:subspecies
|
gptkb:ARF2
gptkb:ARF3
gptkb:ARF4
gptkb:ARF5
gptkb:ARF6
gptkb:ARF1
|
|
gptkbp:bfsParent
|
gptkb:RAS_protein_family
|
|
gptkbp:bfsLayer
|
7
|