Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
guanine nucleotide exchange factors (GEFs)
|
| gptkbp:biologicalProcess |
GTP binding
GTPase activity |
| gptkbp:decommissioned |
gptkb:GDP_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs) |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
cell cycle progression
cell migration gene expression regulation cell polarity regulation of actin cytoskeleton |
| https://www.w3.org/2000/01/rdf-schema#label |
RHO proteins
|
| gptkbp:involves |
gptkb:cancer
cardiovascular diseases neurological disorders |
| gptkbp:memberOf |
gptkb:Ras_superfamily
|
| gptkbp:notableMember |
gptkb:RhoA
gptkb:Rac1 gptkb:Cdc42 |
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation wound healing vesicle trafficking angiogenesis transcriptional activation cell shape neurite outgrowth phagocytosis cell adhesion cytokinesis endocytosis exocytosis immune cell function cell-cell junctions cellular morphogenesis formation of adherens junctions formation of filopodia formation of focal adhesions formation of invadopodia formation of lamellipodia formation of podosomes formation of stress fibers formation of tight junctions cell-matrix interactions oxidative burst in phagocytes |
| gptkbp:subclassOf |
small molecule
|
| gptkbp:bfsParent |
gptkb:RAS_protein_family
|
| gptkbp:bfsLayer |
7
|