Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
superfamily
|
| gptkbp:conservedIn |
GxxxxGKS/T motif
|
| gptkbp:enzymeCommissionNumber |
EC 3.6.5.-
|
| gptkbp:foundIn |
all domains of life
|
| gptkbp:function |
GTP binding
GTP hydrolysis |
| gptkbp:GOProcess |
signal transduction
intracellular transport |
| gptkbp:hasDiseaseAssociation |
neurodegenerative diseases
cancer (via Ras mutations) |
| gptkbp:hasFeature |
nucleotide-binding domain
switch regions |
| gptkbp:hasGOFunction |
GTP binding
GTPase activity |
| gptkbp:hasPfamID |
gptkb:PF00071
|
| gptkbp:hasRole |
signal transduction
vesicle trafficking cell division protein synthesis |
| https://www.w3.org/2000/01/rdf-schema#label |
P-loop GTPases
|
| gptkbp:includes |
gptkb:Arf_family
gptkb:Rab_family gptkb:Ras_family gptkb:Dynamin_family Translation factors (e.g., EF-Tu, EF-G) |
| gptkbp:InterPro |
gptkb:IPR027417
|
| gptkbp:motif |
P-loop (phosphate-binding loop)
|
| gptkbp:regulates |
gptkb:guanine_nucleotide_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs) guanine nucleotide exchange factors (GEFs) |
| gptkbp:subclassOf |
gptkb:P-loop_NTPases
|
| gptkbp:target |
GTPase-activating proteins (GAPs)
|
| gptkbp:bfsParent |
gptkb:RAS_protein_family
|
| gptkbp:bfsLayer |
7
|