|
gptkbp:instanceOf
|
gptkb:superfamily
|
|
gptkbp:conservedIn
|
GxxxxGKS/T motif
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.6.5.-
|
|
gptkbp:foundIn
|
all domains of life
|
|
gptkbp:function
|
GTP binding
GTP hydrolysis
|
|
gptkbp:GOProcess
|
signal transduction
intracellular transport
|
|
gptkbp:hasDiseaseAssociation
|
neurodegenerative diseases
cancer (via Ras mutations)
|
|
gptkbp:hasFeature
|
nucleotide-binding domain
switch regions
|
|
gptkbp:hasGOFunction
|
GTP binding
GTPase activity
|
|
gptkbp:hasPfamID
|
gptkb:PF00071
|
|
gptkbp:hasRole
|
signal transduction
vesicle trafficking
cell division
protein synthesis
|
|
gptkbp:includes
|
gptkb:Arf_family
gptkb:Rab_family
gptkb:Ras_family
gptkb:Dynamin_family
Translation factors (e.g., EF-Tu, EF-G)
|
|
gptkbp:InterPro
|
gptkb:IPR027417
|
|
gptkbp:motif
|
P-loop (phosphate-binding loop)
|
|
gptkbp:regulates
|
gptkb:guanine_nucleotide_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs)
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:subclassOf
|
gptkb:P-loop_NTPases
|
|
gptkbp:target
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:bfsParent
|
gptkb:RAS_protein_family
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P-loop GTPases
|