|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:HRAS
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:associatedWith
|
gptkb:oral_squamous_cell_carcinoma
gptkb:KRAS
gptkb:NRAS
gptkb:cancer
gptkb:Costello_syndrome
bladder cancer
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:encodes
|
gptkb:GTPase_HRas
|
|
gptkbp:Entrez_Gene_ID
|
3265
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:function
|
signal transduction
GTP binding
GTPase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_005343.3
NM_176795.3
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
190020 (HRAS)
|
|
gptkbp:involves
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
chromosome 11
|
|
gptkbp:mutationAssociatedWith
|
missense mutation
codon 12
codon 13
codon 61
oncogenic transformation
gain-of-function mutation
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:orthologInMouse
|
gptkb:Hras1
Hras
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:product
|
small molecule
contains G domain
contains effector domain
contains hypervariable region
|
|
gptkbp:proteinFamily
|
gptkb:RAS_oncogene_family
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:RAS_gene
|
|
gptkbp:bfsLayer
|
5
|