|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:KRAS2
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
gptkb:RASK2
gptkb:c-K-ras
|
|
gptkbp:associatedWith
|
gptkb:HRAS
gptkb:NRAS
gptkb:cancer
colorectal cancer
pancreatic cancer
Noonan syndrome 3
cardiofaciocutaneous syndrome 2
|
|
gptkbp:clinicalTrialPhase
|
KRAS mutation analysis
|
|
gptkbp:discoveredBy
|
gptkb:Der,_Channing_J.
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:KRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
gptkb:KRAS4A
gptkb:KRAS4B
|
|
gptkbp:HGNC_ID
|
6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
190070 (KRAS)
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12p12.1
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
|
|
gptkbp:mutationAssociatedWith
|
nonsense
deletion
missense
codon 12
codon 13
codon 61
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologInMouse
|
gptkb:Kras
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:proteinFamily
|
gptkb:GTP-binding_domain
small molecule
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:targetOfDrug
|
gptkb:adagrasib
gptkb:sotorasib
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:RAS_gene
|
|
gptkbp:bfsLayer
|
5
|