|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NS
gptkb:Ki-ras
gptkb:RASK2
gptkb:c-K-ras
|
|
gptkbp:alternativeSplicing
|
produces two isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:fullName
|
KRAS proto-oncogene, GTPase
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
gptkbp:gene
|
gptkb:KRAS
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasIsoform
|
gptkb:KRAS4A
gptkb:KRAS4B
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
3845 (KRAS)
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
12
|
|
gptkbp:location
|
12p12.1
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:G12V
gptkb:G13D
gptkb:Q61H
G12D
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:oncogene
|
true
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Kras
rat Kras
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:product
|
gptkb:KRAS_protein
|
|
gptkbp:proteinFamily
|
gptkb:Ras_family
gptkb:GTP-binding_domain
|
|
gptkbp:RefSeq
|
gptkb:NM_033360
NM_004985
|
|
gptkbp:regulates
|
regulated by GEFs and GAPs
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:targetOfDrug
|
gptkb:adagrasib
gptkb:sotorasib
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:RAS_gene
|
|
gptkbp:bfsLayer
|
5
|