phosphoinositide 3-kinase (PI3K)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:activatedBy	gptkb:G_protein-coupled_receptors gptkb:Ras_protein gptkb:receptor_tyrosine_kinases
gptkbp:actsOn	phosphatidylinositol phosphatidylinositol 4,5-bisphosphate phosphatidylinositol 4-phosphate
gptkbp:alternativeName	gptkb:PI3K gptkb:protein
gptkbp:catalyzes	phosphorylation of phosphoinositides
gptkbp:discoveredBy	gptkb:Lewis_Cantley
gptkbp:EC_number	2.7.1.153
gptkbp:firstDescribed	1988
gptkbp:foundIn	eukaryotes
gptkbp:gene	gptkb:PIK3CA gptkb:PIK3CB gptkb:PIK3CD gptkb:PIK3CG
gptkbp:hasType	gptkb:Class_III_PI3K gptkb:Class_II_PI3K gptkb:Class_I_PI3K
https://www.w3.org/2000/01/rdf-schema#label	phosphoinositide 3-kinase (PI3K)
gptkbp:inhibitedBy	gptkb:LY294002 gptkb:wortmannin
gptkbp:involvedIn	gptkb:PI3K/AKT_signaling_pathway cell proliferation cell survival cancer progression cell growth regulation metabolism regulation
gptkbp:mutationAssociatedWith	gptkb:cancer gptkb:endometrial_cancer gptkb:glioblastoma colorectal cancer
gptkbp:product	gptkb:phosphatidylinositol_3,4,5-trisphosphate gptkb:phosphatidylinositol_3,4-bisphosphate phosphatidylinositol 3-phosphate
gptkbp:regulates	gptkb:mTOR_pathway apoptosis angiogenesis cell migration glucose metabolism immune response
gptkbp:subunit	p110 catalytic subunit p85 regulatory subunit
gptkbp:target	anticancer drugs
gptkbp:bfsParent	gptkb:buparlisib gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
gptkbp:bfsLayer	6