|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PARP
gptkb:ADPRT
PARP-1
PPOL
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
inflammation
|
|
gptkbp:biologicalProcess
|
chromatin modification
DNA damage response
apoptosis regulation
transcription regulation
NAD+ ADP-ribosyltransferase activity
|
|
gptkbp:discoveredBy
|
Ame J. et al.
|
|
gptkbp:encodes
|
gptkb:Poly_[ADP-ribose]_polymerase_1
|
|
gptkbp:Entrez_Gene_ID
|
142
ENSG00000143799
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:firstDescribed
|
1980
|
|
gptkbp:function
|
DNA repair
poly(ADP-ribosyl)ation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:270
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PARP1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:Olaparib
gptkb:Rucaparib
gptkb:Talazoparib
gptkb:Niraparib
Veliparib
|
|
gptkbp:interactsWith
|
gptkb:DNA-PKcs
gptkb:Ku70
gptkb:Ku80
gptkb:TP53
gptkb:NF-κB
gptkb:XRCC1
gptkb:DNA_ligase_III
Histone H1
|
|
gptkbp:length
|
23 exons
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q42.12
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Fanconi_anemia
|
|
gptkbp:OMIM
|
173870
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Parp1
|
|
gptkbp:product
|
PARP1 protein
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:target
|
PARP inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P09874
|
|
gptkbp:bfsParent
|
gptkb:PARP1
|
|
gptkbp:bfsLayer
|
7
|