Rucaparib

GPTKB entity

Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:drug
PARP inhibitor
gptkbp:approvalYear 2016
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode L01XX54
gptkbp:brand Rubraca
gptkbp:CASNumber 283173-50-2
gptkbp:chemicalFormula C19H18FN3O
gptkbp:contraindication pregnancy
breastfeeding
gptkbp:developer gptkb:Clovis_Oncology
gptkbp:eliminationHalfLife 17-19 hours
gptkbp:hasInChIKey QJQYJQFISDJFHK-UHFFFAOYSA-N
gptkbp:hasSMILES C1=CC(=CC=C1C2=NC(=NC(=N2)N3CCN(CC3)C4=CC=C(C=C4)F)O)C
https://www.w3.org/2000/01/rdf-schema#label Rucaparib
gptkbp:KEGGID D10541
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits PARP enzymes
gptkbp:metabolism hepatic
gptkbp:molecularWeight 421.37 g/mol
gptkbp:patent gptkb:Pfizer
gptkb:Clovis_Oncology
gptkbp:pregnancyCategory D (US)
gptkbp:PubChem_CID 9931957
CHEMBL1214097
DB12372
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
vomiting
abdominal pain
constipation
fatigue
thrombocytopenia
decreased appetite
dysgeusia
gptkbp:target gptkb:PARP1
gptkb:PARP2
gptkb:PARP3
gptkbp:UNII D9F6R8K2J0
gptkbp:usedFor gptkb:cancer
prostate cancer
gptkbp:bfsParent gptkb:PARP1
gptkbp:bfsLayer 7