Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:cofactor |
Mg2+
|
| gptkbp:discoveredBy |
1990s
|
| gptkbp:EC_number |
6.5.1.1
|
| gptkbp:encodedBy |
LIG3 gene
|
| gptkbp:formsComplexWith |
gptkb:XRCC1
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
catalyzes the joining of DNA strand breaks
|
| gptkbp:gene |
LIG3
|
| https://www.w3.org/2000/01/rdf-schema#label |
DNA ligase III
|
| gptkbp:involves |
base excision repair
mitochondrial DNA repair |
| gptkbp:locale |
gptkb:nucleus
mitochondria |
| gptkbp:locatedOnChromosome |
17q12-q21
|
| gptkbp:molecularWeight |
~103 kDa
|
| gptkbp:mutationAssociatedWith |
genomic instability
|
| gptkbp:orthologInMouse |
Lig3
|
| gptkbp:participatedIn |
single-strand break repair
|
| gptkbp:relatedTo |
gptkb:DNA_ligase_I
gptkb:DNA_ligase_IV |
| gptkbp:structure |
contains DNA-binding domain
contains BRCT domain |
| gptkbp:substrate |
gptkb:ATP
NAD+ |
| gptkbp:UniProtID |
P49916
|
| gptkbp:bfsParent |
gptkb:CHEBI:15765
|
| gptkbp:bfsLayer |
7
|