|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:catalyzes
|
poly ADP-ribosylation
|
|
gptkbp:cofactor
|
NAD+
|
|
gptkbp:component
|
nuclear chromatin
|
|
gptkbp:contains
|
gptkb:PARP1
gptkb:PARP2
gptkb:PARP3
PARP4
|
|
gptkbp:database
|
GeneCards: PARP1
HGNC: 270
UniProt: P09874
|
|
gptkbp:discoveredBy
|
gptkb:Paul_Mandel
|
|
gptkbp:discoveredIn
|
1963
|
|
gptkbp:enzymeClassification
|
transferase
|
|
gptkbp:fullName
|
Poly (ADP-ribose) polymerase
|
|
gptkbp:function
|
DNA repair
regulation of gene expression
cell death
poly(ADP-ribose) polymerase activity
|
|
gptkbp:gene
|
gptkb:PARP1
gptkb:PARP2
gptkb:PARP3
PARP4
|
|
gptkbp:GOProcess
|
DNA repair
chromatin modification
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PARP
|
|
gptkbp:inhibitedBy
|
gptkb:Olaparib
gptkb:Rucaparib
gptkb:Talazoparib
gptkb:Niraparib
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:medicalUse
|
targeted cancer therapy
|
|
gptkbp:memberOf
|
PARP family
|
|
gptkbp:mutationAssociatedWith
|
genomic instability
increased sensitivity to DNA damaging agents
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
gptkb:yeast
|
|
gptkbp:relatedTo
|
gptkb:BRCA1
gptkb:BRCA2
DNA damage response
|
|
gptkbp:structure
|
gptkb:BRCT_domain
zinc finger domain
catalytic domain
|
|
gptkbp:target
|
PARP inhibitors
|
|
gptkbp:bfsParent
|
gptkb:PARP1
gptkb:Groupe_Partouche
|
|
gptkbp:bfsLayer
|
7
|