Poly [ADP-ribose] polymerase 1

URI: https://gptkb.org/entity/Poly_[ADP-ribose]_polymerase_1
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:PARP1
gptkb:ADPRT
gptkb:Poly(ADP-ribose)_synthetase_1
gptkbp:biologicalProcess NAD+ ADP-ribosyltransferase activity
gptkbp:discoveredBy gptkb:Pierre_Chambon
gptkbp:discoveredIn 1963
gptkbp:EC_number 2.4.2.30
gptkbp:Entrez_Gene_ID ENSG00000143799
GC01M022282
gptkbp:expressedIn many tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function DNA repair
poly(ADP-ribosyl)ation
gptkbp:gene gptkb:PARP1
gptkbp:GO_term gptkb:GO:0003950
GO:0005634
GO:0006281
gptkbp:HGNC_ID gptkb:HGNC:270
https://www.w3.org/2000/01/rdf-schema#label Poly [ADP-ribose] polymerase 1
gptkbp:interactsWith gptkb:Ku70
gptkb:p53
gptkb:XRCC1
gptkb:DNA_ligase_III
histones
gptkbp:involves base excision repair
cell death
genomic stability
gptkbp:length 1014
gptkbp:locatedOnChromosome gptkb:chromosome_1q42.12
gptkbp:location gptkb:nucleus
gptkbp:molecularWeight 113 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
neurodegeneration
gptkbp:OMIM 173870
gptkbp:orthologInMouse Parp1
gptkbp:PDB 4DQY
gptkbp:RefSeq gptkb:NP_001609.2
gptkbp:regulates transcription
chromatin structure
gptkbp:targetOfDrug gptkb:Olaparib
gptkb:Rucaparib
gptkb:Talazoparib
gptkb:Niraparib
gptkbp:UniProtID gptkb:P09874
gptkbp:bfsParent gptkb:PARP1
gptkbp:bfsLayer 7