|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PRKDC
XRCC7
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:component
|
DNA-PK complex
|
|
gptkbp:discoveredBy
|
gptkb:David_J._Chen
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000108375
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.1
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:family
|
PIKK family
|
|
gptkbp:fullName
|
DNA-dependent protein kinase catalytic subunit
|
|
gptkbp:function
|
gptkb:non-homologous_end_joining
DNA double-strand break repair
|
|
gptkbp:gene
|
gptkb:PRKDC
|
|
gptkbp:GOID
|
GO:0004672
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNA-PKcs
|
|
gptkbp:inhibitedBy
|
gptkb:NU7441
gptkb:wortmannin
|
|
gptkbp:interactsWith
|
Ku70/Ku80 heterodimer
|
|
gptkbp:involvedIn
|
gptkb:V(D)J_recombination
cellular response to DNA damage
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
chromosome 8q11
|
|
gptkbp:molecularWeight
|
~469 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
|
|
gptkbp:OMIM
|
600899
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
5LUQ
|
|
gptkbp:phosphorylates
|
gptkb:H2AX
gptkb:p53
Ser2056
Thr2609
XRCC4
|
|
gptkbp:postTranslationalModification
|
autophosphorylation
|
|
gptkbp:RefSeq
|
NP_006440
|
|
gptkbp:regulates
|
DNA repair pathway choice
|
|
gptkbp:requires
|
genomic stability
lymphocyte development
|
|
gptkbp:reviewedBy
|
gptkb:science
gptkb:Nature_Reviews_Molecular_Cell_Biology
Cell
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:structure
|
serine/threonine protein kinase
|
|
gptkbp:UniProtID
|
gptkb:P78527
|
|
gptkbp:bfsParent
|
gptkb:DNA-PK
|
|
gptkbp:bfsLayer
|
6
|