Mechanistic target of rapamycin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene gptkb:enzyme
gptkbp:alias	gptkb:SKS gptkb:SEP gptkb:FRAP1 RAFT1 RAPT1
gptkbp:associatedWith	gptkb:tuberous_sclerosis gptkb:cancer gptkb:diabetes neurodegenerative diseases
gptkbp:discoveredBy	gptkb:David_M._Sabatini
gptkbp:EC_number	2.7.11.1
gptkbp:encodedBy	gptkb:MTOR_gene
gptkbp:formsComplexWith	gptkb:mTORC1 gptkb:mTORC2
gptkbp:function	regulation of cell proliferation regulation of cell survival regulation of autophagy regulation of cell growth regulation of cell motility regulation of protein synthesis
https://www.w3.org/2000/01/rdf-schema#label	Mechanistic target of rapamycin
gptkbp:inhibitedBy	gptkb:everolimus gptkb:rapamycin gptkb:sirolimus gptkb:temsirolimus
gptkbp:locatedOnChromosome	gptkb:1p36.2
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:memberOf	gptkb:PI3K/AKT/mTOR_pathway
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	TOR (yeast)
gptkbp:phosphorylates	gptkb:4EBP1 gptkb:S6K1 gptkb:ULK1 gptkb:AKT
gptkbp:regulates	aging metabolism angiogenesis lipid synthesis immune response
gptkbp:symbol	gptkb:mTOR
gptkbp:UniProtID	gptkb:P42345
gptkbp:bfsParent	gptkb:P49841
gptkbp:bfsLayer	7