Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:activatedBy |
MAPKKK (e.g., RAF1)
|
| gptkbp:alsoKnownAs |
gptkb:MEK2
gptkb:MAP2K2 |
| gptkbp:associatedWith |
gptkb:cancer
|
| gptkbp:biologicalProcess |
apoptosis
cell proliferation differentiation protein kinase activity |
| gptkbp:encodes |
gptkb:Mitogen-activated_protein_kinase_kinase_2
|
| gptkbp:Entrez_Gene_ID |
5605
|
| gptkbp:enzymeCommissionNumber |
2.7.12.2
|
| gptkbp:function |
phosphorylates and activates MAP kinases
|
| gptkbp:geneType |
protein-coding
|
| gptkbp:hasTranscriptVariant |
multiple
|
| gptkbp:HGNC_ID |
6840
|
| https://www.w3.org/2000/01/rdf-schema#label |
MAPKK2
|
| gptkbp:inhibitedBy |
MEK inhibitors (e.g., U0126, PD98059)
|
| gptkbp:involvedIn |
gptkb:MAPK/ERK_signaling_pathway
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Map2k2
|
| gptkbp:phosphorylates |
MAPK1 (ERK2)
MAPK3 (ERK1) |
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:UniProtID |
P36507
|
| gptkbp:bfsParent |
gptkb:MEK2
|
| gptkbp:bfsLayer |
6
|