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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:MEK2
gptkb:MAP2K2
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:domain
|
protein kinase domain
|
|
gptkbp:encodedBy
|
gptkb:MAP2K2_gene
|
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gptkbp:Entrez_Gene_ID
|
5605
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.12.2
|
|
gptkbp:function
|
phosphorylates and activates MAP kinases
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP kinase kinase 2
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:length
|
400
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3EQF
|
|
gptkbp:phosphorylates
|
gptkb:ERK1
gptkb:ERK2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:target
|
gptkb:MEK_inhibitors
|
|
gptkbp:UniProtID
|
P36507
|
|
gptkbp:bfsParent
|
gptkb:MEK2
|
|
gptkbp:bfsLayer
|
6
|