Mitogen-activated protein kinase kinase 2

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_kinase_2
GPTKB entity
Statements (39)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:MEK2
gptkb:MAPKK2
gptkb:PRKMK2
gptkbp:associatedWith gptkb:cancer
gptkb:Noonan_syndrome
gptkbp:biologicalProcess cell differentiation
cell proliferation
apoptosis regulation
protein serine/threonine kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:EC_number 2.7.12.2
gptkbp:encodedBy gptkb:MAP2K2_gene
gptkbp:Entrez_Gene_ID 5605
gptkbp:function phosphorylates and activates MAP kinases
involved in MAPK/ERK signaling pathway
gptkbp:HGNC_ID 6840
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase kinase 2
gptkbp:inhibitedBy gptkb:Selumetinib
gptkb:Trametinib
gptkbp:length 400 amino acids
gptkbp:locatedOnChromosome gptkb:19p13.3
gptkbp:molecularWeight 44 kDa
gptkbp:OMIM 601263
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:mouse_Map2k2
rat Map2k2
gptkbp:pathway gptkb:MAPK_signaling_pathway
gptkbp:PDB 3EQF
gptkbp:phosphorylates RAF kinases
gptkbp:postTranslationalModification phosphorylation
gptkbp:RefSeq gptkb:NM_030662
gptkbp:substrate MAPK1 (ERK2)
MAPK3 (ERK1)
gptkbp:UniProtID P36507
gptkbp:bfsParent gptkb:MEK2
gptkbp:bfsLayer 6