|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
cytokines
stress signals
inflammatory signals
UV irradiation
phosphorylation on threonine and tyrosine residues
|
|
gptkbp:alternativeName
|
Stress-activated protein kinase
SAPK
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:downstreamOf
|
gptkb:ATF2
gptkb:c-Jun
|
|
gptkbp:encodedBy
|
gptkb:MAPK9_gene
gptkb:MAPK8_gene
MAPK10 gene
|
|
gptkbp:fullName
|
gptkb:c-Jun_N-terminal_kinase
|
|
gptkbp:function
|
regulates gene expression
phosphorylates c-Jun
|
|
gptkbp:hasIsoform
|
gptkb:JNK1
gptkb:JNK2
gptkb:JNK3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JNK MAPK
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
inflammatory response
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
transcription factors
|
|
gptkbp:regulates
|
gptkb:AP-1_transcription_factor
cell survival
immune response
|
|
gptkbp:relatedTo
|
gptkb:p38_MAPK
ERK MAPK
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
contains kinase domain
|
|
gptkbp:subclassOf
|
serine/threonine kinase
|
|
gptkbp:target
|
pharmacological inhibitors
|
|
gptkbp:upstreamActivator
|
gptkb:MAP2K4
gptkb:MAP2K7
|
|
gptkbp:bfsParent
|
gptkb:DUSP10
|
|
gptkbp:bfsLayer
|
7
|