|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
cytokines
heat shock
osmotic shock
reactive oxygen species
UV irradiation
|
|
gptkbp:alternativeName
|
gptkb:JNK
Stress-activated protein kinase
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:EC_number
|
2.7.11.24
|
|
gptkbp:encodedBy
|
gptkb:MAPK9_gene
gptkb:MAPK8_gene
MAPK10 gene
|
|
gptkbp:function
|
involved in inflammation
regulates gene expression
involved in apoptosis
involved in stress response
phosphorylates c-Jun
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Jun N-terminal kinase
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:JNK_subgroup
|
|
gptkbp:phosphorylates
|
gptkb:Bcl-2
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
gptkb:p53
|
|
gptkbp:relatedTo
|
gptkb:MAPK_pathway
gptkb:cancer
gptkb:diabetes
cell differentiation
cell proliferation
obesity
neurodegenerative diseases
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:substrate
|
gptkb:Bcl-2
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
gptkb:p53
|
|
gptkbp:UniProtID
|
gptkb:P45983
gptkb:P53779
P45984
|
|
gptkbp:bfsParent
|
gptkb:JNK
|
|
gptkbp:bfsLayer
|
7
|