JNK (c-Jun N-terminal kinase)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	cytokines UV radiation oxidative stress DNA damage environmental stress heat shock osmotic shock
gptkbp:alternativeName	Stress-activated protein kinase (SAPK)
gptkbp:discoveredIn	1990s
gptkbp:EC_number	2.7.11.24
gptkbp:encodedBy	gptkb:MAPK10 gptkb:MAPK9 gptkb:MAPK8
gptkbp:foundIn	gptkb:yeast gptkb:Drosophila_melanogaster mammals
gptkbp:hasIsoform	gptkb:JNK1 gptkb:JNK2 gptkb:JNK3
https://www.w3.org/2000/01/rdf-schema#label	JNK (c-Jun N-terminal kinase)
gptkbp:inhibitedBy	gptkb:SP600125
gptkbp:involvedIn	gptkb:cancer gptkb:diabetes apoptosis cell differentiation cell proliferation neurodegenerative diseases inflammatory diseases inflammatory response
gptkbp:locale	gptkb:nucleus gptkb:cytoplasm
gptkbp:memberOf	gptkb:MAP_kinase_family
gptkbp:PDB	gptkb:4AWI 3V6S 2XRW
gptkbp:phosphorylates	gptkb:Bcl-2 gptkb:ATF2 gptkb:Elk-1 gptkb:c-Jun gptkb:p53 gptkb:c-Fos
gptkbp:regulates	gene expression transcription factors
gptkbp:UniProtID	gptkb:P45983 gptkb:P53779 P45984
gptkbp:bfsParent	gptkb:Mitogen-activated_protein_kinases_(MAPKs) gptkb:Mitogen-activated_protein_kinase_pathway gptkb:SP600125
gptkbp:bfsLayer	7