Mitogen-activated protein kinases (MAPKs)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	cytokines growth factors mitogens osmotic stress
gptkbp:alternativeName	gptkb:MAPK gptkb:ERK_(extracellular_signal-regulated_kinase) gptkb:JNK_(c-Jun_N-terminal_kinase) gptkb:p38_MAPK MAP kinase
gptkbp:contains	gptkb:MAPK/ERK_pathway gptkb:JNK_pathway gptkb:p38_MAPK_pathway
gptkbp:discoveredBy	gptkb:Edwin_G._Krebs gptkb:Edmond_H._Fischer
gptkbp:downstreamOf	transcription factors cytoskeletal proteins other kinases
gptkbp:EC_number	2.7.11.24
gptkbp:foundIn	eukaryotes
gptkbp:function	phosphorylation of proteins
gptkbp:GO_term	GO:0000165
https://www.w3.org/2000/01/rdf-schema#label	Mitogen-activated protein kinases (MAPKs)
gptkbp:inhibitedBy	MAPK inhibitors
gptkbp:involvedIn	apoptosis cell differentiation cell proliferation cell survival signal transduction cellular response to stimuli
gptkbp:locale	gptkb:nucleus gptkb:cytoplasm
gptkbp:memberOf	gptkb:protein_kinase_superfamily
gptkbp:phosphorylates	serine residues threonine residues
gptkbp:regulates	transcription factors cytoskeletal proteins other kinases phosphorylation cascade
gptkbp:relatedTo	gptkb:cancer neurodegenerative diseases autoimmune diseases inflammation
gptkbp:structure	protein domain with kinase activity
gptkbp:subclassOf	serine/threonine-specific protein kinase
gptkbp:upregulatedBy	MAPKK (MAP kinase kinase) MAPKKK (MAP kinase kinase kinase)
gptkbp:bfsParent	gptkb:MAPK/ERK_signaling_pathway
gptkbp:bfsLayer	6