|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD221
gptkb:Insulin-like_growth_factor_1_receptor
IGFR
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:downregulated_by
|
IGF-1R inhibitors
|
|
gptkbp:downstream_pathway
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
|
|
gptkbp:encodedBy
|
gptkb:IGF1R_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000140443
|
|
gptkbp:expressed_during
|
embryonic development
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
binds insulin-like growth factor 1
mediates cell differentiation
mediates cell growth
mediates cell survival
mediates cell transformation
|
|
gptkbp:gene
|
gptkb:IGF1R
|
|
gptkbp:has_enzymatic_activity
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:HGNC_ID
|
5465
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF-1 receptor
|
|
gptkbp:involves
|
gptkb:cancer
aging
growth disorders
|
|
gptkbp:ligand
|
gptkb:insulin-like_growth_factor_2
gptkb:insulin-like_growth_factor_1
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
19q13.32
|
|
gptkbp:molecularWeight
|
~180 kDa (precursor)
|
|
gptkbp:mutationAssociatedWith
|
growth retardation
|
|
gptkbp:OMIM
|
147370
|
|
gptkbp:orthologInMouse
|
gptkb:Igf1r
|
|
gptkbp:PDB
|
3D94
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:RefSeq
|
gptkb:NM_000875
|
|
gptkbp:relatedTo
|
gptkb:insulin_receptor
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Cancer
|
|
gptkbp:role
|
cell proliferation
metabolism
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
|
|
gptkbp:target
|
therapeutic antibodies
monoclonal antibodies
tyrosine kinase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P08069
|
|
gptkbp:bfsParent
|
gptkb:IGF-II
gptkb:insulin-like_growth_factors
|
|
gptkbp:bfsLayer
|
7
|