|
gptkbp:instanceOf
|
gptkb:protein
growth factor
|
|
gptkbp:abbreviation
|
gptkb:IGF2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
gptkb:IGF_binding_proteins
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
gptkb:IGF2_gene
|
|
gptkbp:expressedIn
|
embryonic development
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor_2
|
|
gptkbp:function
|
cell differentiation
cell proliferation
fetal development
regulation of growth and development
|
|
gptkbp:gene
|
gptkb:IGF2
|
|
gptkbp:halfLife
|
short in plasma
|
|
gptkbp:HGNC_ID
|
5466
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF-II
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:Beckwith-Wiedemann_syndrome
gptkb:Silver-Russell_syndrome
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11p15.5_(human)
|
|
gptkbp:medicalUse
|
biomarker for certain cancers
|
|
gptkbp:molecularWeight
|
7.5 kDa
|
|
gptkbp:mutationAssociatedWith
|
growth disorders
tumorigenesis
|
|
gptkbp:OMIM
|
147470
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
|
gptkbp:recipient
|
gptkb:insulin_receptor
gptkb:IGF-1_receptor
gptkb:IGF-2_receptor
|
|
gptkbp:regulates
|
imprinted gene
paternally expressed
|
|
gptkbp:relatedTo
|
gptkb:insulin
gptkb:IGF-I
|
|
gptkbp:role
|
cell survival
metabolism
prenatal growth
tissue repair
|
|
gptkbp:secretes
|
gptkb:placenta
liver
other tissues
|
|
gptkbp:sequenceSimilarity
|
gptkb:insulin_family
|
|
gptkbp:structure
|
polypeptide
|
|
gptkbp:UniProtID
|
P01344
|
|
gptkbp:bfsParent
|
gptkb:IGF2
|
|
gptkbp:bfsLayer
|
6
|