|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:HHG-1
gptkb:Sonic_hedgehog_homolog
HPE3
|
|
gptkbp:coReceptor
|
gptkb:Smoothened_(SMO)
|
|
gptkbp:discoveredBy
|
gptkb:Andrew_P._McMahon
gptkb:Clifford_Tabin
gptkb:Philip_Ingham
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
gptkb:Sonic_Hedgehog_protein
|
|
gptkbp:Entrez_Gene_ID
|
6469
ENSG00000164690
|
|
gptkbp:expressedIn
|
notochord
developing brain
developing limbs
floor plate
|
|
gptkbp:fullName
|
gptkb:Sonic_Hedgehog
|
|
gptkbp:function
|
signaling molecule in embryonic development
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
10848
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SHH
|
|
gptkbp:involvedIn
|
cell growth
limb development
cell specialization
patterning of the neural tube
|
|
gptkbp:length
|
462 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q36
|
|
gptkbp:molecularWeight
|
49 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Gorlin_syndrome
gptkb:holoprosencephaly
basal cell carcinoma
|
|
gptkbp:OMIM
|
600725
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
Drosophila melanogaster (as hedgehog)
|
|
gptkbp:pathway
|
gptkb:Hedgehog_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
palmitoylation
autoproteolytic cleavage
cholesterol modification
|
|
gptkbp:proteinFamily
|
gptkb:hedgehog_signaling_proteins
|
|
gptkbp:recipient
|
gptkb:PTCH1
gptkb:PTCH2
|
|
gptkbp:regulates
|
gptkb:GLI_transcription_factors
cell fate determination
|
|
gptkbp:relatedTo
|
gptkb:cancer
developmental disorders
|
|
gptkbp:species
|
gptkb:human
|
|
gptkbp:symbol
|
gptkb:SHH
|
|
gptkbp:UniProtID
|
gptkb:Q15465
|
|
gptkbp:bfsParent
|
gptkb:Shanghai_Railway_Station
gptkb:Shanghai_South_Railway_Station
gptkb:medulloblastoma
gptkb:Shanghai_West_Railway_Station
|
|
gptkbp:bfsLayer
|
6
|