Suppressor of Fused (SUFU)

URI: https://gptkb.org/entity/Suppressor_of_Fused_(SUFU)
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName SUFUH
Suppressor of fused homolog
gptkbp:associatedWith gptkb:medulloblastoma
basal cell carcinoma
gptkbp:encodedBy SUFU gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000170558
SUFU
gptkbp:firstDescribed 1999
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function negative regulator of Hedgehog signaling pathway
gptkbp:gene SUFU
gptkbp:HGNC_ID HGNC:16937
https://www.w3.org/2000/01/rdf-schema#label Suppressor of Fused (SUFU)
gptkbp:interactsWith gptkb:GLI3
gptkb:GLI1
GLI2
gptkbp:locatedOnChromosome 10q24.32
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 53 kDa
gptkbp:mutationAssociatedWith gptkb:Gorlin_syndrome
gptkbp:OMIM 607035
gptkbp:ortholog_in_Drosophila Suppressor of fused (Su(fu))
gptkbp:PDB 4KM9
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates gptkb:GLI_transcription_factors
Hedgehog pathway activity
gptkbp:UniProtID Q9UMX1
gptkbp:bfsParent gptkb:Hedgehog_signaling_pathway
gptkbp:bfsLayer 7