Suppressor of Fused (SUFU)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	SUFUH Suppressor of fused homolog
gptkbp:associatedWith	gptkb:medulloblastoma basal cell carcinoma
gptkbp:encodedBy	SUFU gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000170558 SUFU
gptkbp:firstDescribed	1999
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	negative regulator of Hedgehog signaling pathway
gptkbp:gene	SUFU
gptkbp:HGNC_ID	HGNC:16937
gptkbp:interactsWith	gptkb:GLI3 gptkb:GLI1 GLI2
gptkbp:locatedOnChromosome	10q24.32
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	53 kDa
gptkbp:mutationAssociatedWith	gptkb:Gorlin_syndrome
gptkbp:OMIM	607035
gptkbp:ortholog_in_Drosophila	Suppressor of fused (Su(fu))
gptkbp:PDB	4KM9
gptkbp:postTranslationalModification	phosphorylation ubiquitination
gptkbp:regulates	gptkb:GLI_transcription_factors Hedgehog pathway activity
gptkbp:UniProtID	Q9UMX1
gptkbp:bfsParent	gptkb:Hedgehog_signaling_pathway
gptkbp:bfsLayer	8
http://www.w3.org/2000/01/rdf-schema#label	Suppressor of Fused (SUFU)