|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:GLI
GLI-1
glioma-associated oncogene homolog 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:medulloblastoma
basal cell carcinoma
|
|
gptkbp:discoveredBy
|
gptkb:Yusuke_Nakamura
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodes
|
GLI1 protein
|
|
gptkbp:Entrez_Gene_ID
|
2735
ENSG00000111087
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
GLI family zinc finger 1
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:4317
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GLI1
|
|
gptkbp:inhibitedBy
|
gptkb:arsenic_trioxide
gptkb:cyclopamine
GANT61
|
|
gptkbp:involvedIn
|
gptkb:Hedgehog_signaling_pathway
|
|
gptkbp:length
|
1106 amino acids
|
|
gptkbp:locatedOnChromosome
|
12q13.3
|
|
gptkbp:molecularWeight
|
118 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
165220
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Gli1
|
|
gptkbp:PDB
|
2GLI
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
zinc finger
|
|
gptkbp:regulates
|
gptkb:GLI3
apoptosis
cell differentiation
cell proliferation
gene expression
GLI2
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:Hedgehog_ligands
SMO (Smoothened)
SUFU (Suppressor of Fused)
|
|
gptkbp:transcriptionalActivator
|
true
|
|
gptkbp:UniProtID
|
P08151
|
|
gptkbp:bfsParent
|
gptkb:DYRK1A
gptkb:Hedgehog_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|