|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:Transforming_protein_p21
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
3265
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HRAS protein
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:GDP
gptkb:RAF1
gptkb:SOS1
gptkb:GTP
|
|
gptkbp:involvedIn
|
cell differentiation
cell division
cell growth regulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:memberOf
|
gptkb:RAS_protein_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
gptkb:head_and_neck_squamous_cell_carcinoma
bladder cancer
missense mutation
oncogenic mutation
gain-of-function mutation
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
GTPase-activating proteins (GAPs)
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:relatedTo
|
gptkb:KRAS_protein
gptkb:NRAS_protein
|
|
gptkbp:structure
|
gptkb:G-domain
gptkb:Switch_II_region
gptkb:Switch_I_region
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:C-H-RAS
|
|
gptkbp:bfsLayer
|
6
|