|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ERBB
gptkb:ERBB1
gptkb:HER1
mENA
|
|
gptkbp:approvedBy
|
gptkb:epidermal_growth_factor_receptor
|
|
gptkbp:approvedSymbol
|
gptkb:EGFR
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
|
|
gptkbp:domain
|
intracellular domain
transmembrane domain
extracellular ligand-binding domain
tyrosine kinase domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146648
1956
|
|
gptkbp:fullName
|
gptkb:epidermal_growth_factor_receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:gene
|
gptkb:EGFR
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:hasTranscriptVariant
|
NM_005228.5
NM_001346897.1
NM_201282.2
NM_201283.2
NM_201284.2
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3685
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:3685
|
|
gptkbp:length
|
1210 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:locusType
|
protein-coding
|
|
gptkbp:molecularWeight
|
134 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:L858R
gptkb:T790M
exon 19 deletion
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:orthologIn
|
gptkb:mouse_Egfr
gptkb:rat_Egfr
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:ErbB_signaling_pathway
|
|
gptkbp:product
|
gptkb:epidermal_growth_factor_receptor
|
|
gptkbp:proteinFamily
|
protein tyrosine kinase family
EGF receptor family
|
|
gptkbp:RefSeq
|
NM_005228
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
|
|
gptkbp:UniProtID
|
gptkb:P00533
|
|
gptkbp:bfsParent
|
gptkb:CD331
gptkb:CD334
|
|
gptkbp:bfsLayer
|
7
|