Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
MEKK2
MEKK3 |
| gptkbp:alternativeName |
gptkb:MAP2K5
Mitogen-activated protein kinase kinase 5 |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:cardiovascular_disease |
| gptkbp:biologicalProcess |
cell signaling
MAPK cascade protein serine/threonine kinase activity |
| gptkbp:cellularComponent |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:EC_number |
2.7.12.2
|
| gptkbp:encodedBy |
MAP2K5 gene
|
| gptkbp:function |
phosphorylates and activates ERK5
|
| https://www.w3.org/2000/01/rdf-schema#label |
MEK5
|
| gptkbp:inhibitedBy |
gptkb:BIX02189
BIX02188 |
| gptkbp:locatedOnChromosome |
15q23
|
| gptkbp:memberOf |
gptkb:MAP_kinase_kinase_family
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:phosphorylates |
Ser311
Thr315 |
| gptkbp:regulates |
cell differentiation
cell proliferation cell survival |
| gptkbp:substrate |
gptkb:ERK5
|
| gptkbp:UniProtID |
Q13163
|
| gptkbp:bfsParent |
gptkb:ERK5_pathway
|
| gptkbp:bfsLayer |
7
|