|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
HER2
neu
|
|
gptkbp:associatedWith
|
gptkb:cancer
bladder cancer
gastric cancer
|
|
gptkbp:clinicalTrialPhase
|
HER2/neu test
|
|
gptkbp:discoveredBy
|
A. Ullrich et al.
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodes
|
Receptor tyrosine-protein kinase erbB-2
|
|
gptkbp:Entrez_Gene_ID
|
2064
ENSG00000141736
|
|
gptkbp:expressedIn
|
epithelial cells
breast tissue
ovarian tissue
lung tissue
gastric tissue
|
|
gptkbp:function
|
cell differentiation
signal transduction
cell growth regulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasBiomarker
|
gptkb:HER2-positive_breast_cancer
HER2-positive gastric cancer
|
|
gptkbp:hasParalog
|
gptkb:EGFR
gptkb:ERBB3
gptkb:ERBB4
|
|
gptkbp:HGNC_ID
|
3430
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERBB2 gene
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:ERBB3
gptkb:SHC1
gptkb:PIK3CA
gptkb:ERBB4
GRB7
|
|
gptkbp:length
|
1255 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
gptkb:17q12
|
|
gptkbp:memberOf
|
gptkb:EGFR_family
|
|
gptkbp:molecularWeight
|
138 kDa
|
|
gptkbp:mutationAssociatedWith
|
amplification
overexpression
|
|
gptkbp:OMIM
|
164870
|
|
gptkbp:orthologInMouse
|
Erbb2
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:ErbB_signaling_pathway
|
|
gptkbp:product
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:targetOfDrug
|
gptkb:ado-trastuzumab_emtansine
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:tucatinib
gptkb:lapatinib
gptkb:neratinib
|
|
gptkbp:UniProtID
|
gptkb:P04626
|
|
gptkbp:bfsParent
|
gptkb:HER2/neu
gptkb:HER2/neu_receptor
gptkb:HER2-positive_breast_cancer
gptkb:HER2_receptor
gptkb:Her2
gptkb:HER2_protein
|
|
gptkbp:bfsLayer
|
7
|