Statements (99)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:catalyzes |
transfer of ubiquitin to substrate proteins
|
| gptkbp:contains |
HECT-type E3 ligases
RBR-type E3 ligases RING-type E3 ligases |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases |
| gptkbp:example |
gptkb:RNF8
gptkb:ITCH gptkb:NEDD4 gptkb:SMURF1 gptkb:WWP1 gptkb:WWP2 gptkb:DDB1 gptkb:CHIP gptkb:APC/C gptkb:MDM2 gptkb:Parkin gptkb:UBE3A gptkb:FBXW7 gptkb:HUWE1 gptkb:RNF168 gptkb:TRAF6 gptkb:SAG gptkb:c-Cbl gptkb:RNF12 gptkb:VHL gptkb:SPOP gptkb:XIAP CUL1 CUL2 CUL3 CUL5 RNF43 SCF complex RNF123 RNF180 RNF185 RNF20 RNF213 RNF216 RNF220 RNF223 RNF224 RNF225 RNF226 RNF227 RNF228 RNF31 RNF4 RNF40 RNF41 RNF5 RNF6 RNF7 RNF111 RNF186 RNF187 KEAP1 UHRF1 RNF14 CRL1 CRL2 CRL3 CRL4 CRL5 CRL7 CRL9 CUL4 CUL7 CUL9 Cbl-b FBXL2 FBXL3 FBXL5 FBXO31 FBXO4 FBXW11 HECW1 LUBAC MARCH family Mule (ARF-BP1) SIAH1 SOCS box proteins TRIM family β-TrCP |
| gptkbp:function |
ubiquitin-protein ligase activity
|
| https://www.w3.org/2000/01/rdf-schema#label |
E3 ligases
|
| gptkbp:interactsWith |
E2 ubiquitin-conjugating enzymes
|
| gptkbp:involvedIn |
signal transduction
DNA repair cell cycle regulation immune response protein degradation |
| gptkbp:role |
ubiquitin-proteasome system
|
| gptkbp:bfsParent |
gptkb:SUMO2
gptkb:SUMO3 |
| gptkbp:bfsLayer |
8
|