|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
MGC126218
MGC126219
hSPOP
speckle-type POZ protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:endometrial_cancer
prostate cancer
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:domain
|
BTB/POZ domain
MATH domain
|
|
gptkbp:encodes
|
speckle-type POZ protein
|
|
gptkbp:Entrez_Gene_ID
|
8405
ENSG00000145041
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
speckle-type POZ protein
|
|
gptkbp:function
|
E3 ubiquitin ligase adaptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:11290
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SPOP
|
|
gptkbp:interactsWith
|
gptkb:PTEN
gptkb:GLI3
gptkb:DAXX
CUL3
GLI2
SRC-3
|
|
gptkbp:involvedIn
|
protein ubiquitination
|
|
gptkbp:length
|
374 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:mutationAssociatedWith
|
nonsense
missense
frameshift
oncogenic potential
|
|
gptkbp:OMIM
|
602277
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:pathway
|
gptkb:Hedgehog_signaling_pathway
cell cycle regulation
ubiquitin-mediated proteolysis
|
|
gptkbp:PDB
|
3HQI
|
|
gptkbp:regulates
|
transcription factors
signal transduction proteins
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:significance
|
biomarker for prostate cancer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
nuclear speckles
|
|
gptkbp:UniProtID
|
O43791
|
|
gptkbp:bfsParent
|
gptkb:Single_Point_of_Presence
|
|
gptkbp:bfsLayer
|
6
|