Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:ATR_protein
|
| gptkbp:application |
BRC A1
|
| gptkbp:associated_with |
tumor suppression
|
| gptkbp:discovered_by |
gptkb:Dr._David_Lane
|
| gptkbp:established |
gptkb:ATR_kinase
apoptosis DNA repair mechanisms DNA damage certain small molecules cell proliferation under stress used in cancer therapy |
| gptkbp:function |
phosphorylates proteins
|
| gptkbp:genetic_diversity |
various cancers
linked to cancer risk |
| gptkbp:has_role |
cellular signaling pathways
G1/ S checkpoint |
| https://www.w3.org/2000/01/rdf-schema#label |
checkpoint kinase 2
|
| gptkbp:interacts_with |
gptkb:p53
|
| gptkbp:is_aimed_at |
therapeutic agents
|
| gptkbp:is_associated_with |
genetic predisposition to cancer
hereditary breast cancer chemosensitivity |
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_involved_in |
DNA damage response
cell cycle regulation cellular homeostasis cellular stress response tumorigenesis cellular differentiation cellular signaling pathways cellular signaling tumor progression cellular repair mechanisms cellular growth control cellular repair processes cellular apoptosis cellular apoptosis pathways apoptotic signaling response to ionizing radiation cellular repair response cellular cycle checkpoints tumor suppression pathways |
| gptkbp:is_linked_to |
gptkb:psychologist
gptkb:Li-Fraumeni_syndrome cancer metastasis breast cancer susceptibility |
| gptkbp:is_part_of |
DNA damage checkpoint
checkpoint signaling pathway |
| gptkbp:is_represented_in |
various tissues
breast tissue lung tissue prostate tissue ovarian tissue skin tissue colon tissue |
| gptkbp:located_in |
gptkb:physicist
|
| gptkbp:promoter |
CHE K2
|
| gptkbp:regulates |
gptkb:ATM_kinase
cellular senescence p53 protein cell cycle checkpoints cellular response to DNA damage cellular stress signals |