|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:ATM_kinase
|
|
gptkbp:alternativeName
|
gptkb:CHK2
Rad53
Cds1
|
|
gptkbp:associatedWith
|
gptkb:hereditary_breast_cancer
gptkb:Li-Fraumeni_syndrome
prostate cancer
|
|
gptkbp:biologicalProcess
|
serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
1999
|
|
gptkbp:encodedBy
|
CHEK2 gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:function
|
DNA damage response
cell cycle checkpoint regulation
phosphorylation of target proteins
|
|
gptkbp:HGNC_ID
|
16627
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
checkpoint kinase 2
|
|
gptkbp:inhibitedBy
|
small molecule inhibitors
|
|
gptkbp:involves
|
gptkb:G1/S_checkpoint
G2/M checkpoint
|
|
gptkbp:locatedOnChromosome
|
22q12.1
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
|
|
gptkbp:OMIM
|
604373
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Chek2
|
|
gptkbp:orthologInYeast
|
Rad53
|
|
gptkbp:PDB
|
2CN5
|
|
gptkbp:phosphorylates
|
gptkb:CDC25C
gptkb:BRCA1
gptkb:E2F1
gptkb:p53
|
|
gptkbp:product
|
gptkb:CHEK2
|
|
gptkbp:regulates
|
apoptosis
DNA repair
cell cycle arrest
|
|
gptkbp:structure
|
contains kinase domain
contains FHA domain
|
|
gptkbp:UniProtID
|
O96017
|
|
gptkbp:bfsParent
|
gptkb:CHEK2
|
|
gptkbp:bfsLayer
|
7
|