|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
CDC25 homolog C
M-phase inducer phosphatase 3
cell division cycle 25C
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
gptkb:protein
G2/M transition
mitotic entry
|
|
gptkbp:discoveredBy
|
gptkb:David_Beach
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
CDC25C gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000158402
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
cell cycle regulation
activation of cyclin-dependent kinases
|
|
gptkbp:gene
|
CDC25C (human gene)
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1724
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDC25C
|
|
gptkbp:inhibitedBy
|
gptkb:14-3-3_proteins
|
|
gptkbp:interactsWith
|
gptkb:CDK1
gptkb:cyclin_B1
|
|
gptkbp:involvedIn
|
cell proliferation
DNA damage checkpoint
|
|
gptkbp:length
|
473 amino acids
|
|
gptkbp:location
|
gptkb:chromosome_5q31
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
157680
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
5C2T
|
|
gptkbp:phosphorylates
|
gptkb:MAPK
gptkb:CHEK2
gptkb:PLK1
gptkb:CHEK1
|
|
gptkbp:RefSeq
|
NM_001789
|
|
gptkbp:regulates
|
phosphorylation
ubiquitination
nuclear export
proteasomal degradation
CDK1/cyclin B complex
|
|
gptkbp:significance
|
therapeutic target
potential cancer biomarker
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P30307
|
|
gptkbp:bfsParent
|
gptkb:CDK1_gene
gptkb:CDK1
|
|
gptkbp:bfsLayer
|
6
|