Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:activatedBy |
Mec1
Tel1 |
| gptkbp:alias |
MEC2
RSR1 SAD1 SPK1 |
| gptkbp:encodes |
Rad53p
|
| gptkbp:Entrez_Gene_ID |
855422
YPL153C |
| gptkbp:foundIn |
gptkb:Saccharomyces_cerevisiae
|
| gptkbp:function |
DNA repair
cell cycle regulation DNA damage checkpoint |
| gptkbp:GO_term |
GO:0004672 (protein kinase activity)
GO:0005515 (protein binding) GO:0000077 (DNA damage checkpoint) |
| https://www.w3.org/2000/01/rdf-schema#label |
RAD53
|
| gptkbp:length |
821 amino acids
|
| gptkbp:locatedOnChromosome |
Chromosome XVI
|
| gptkbp:molecularWeight |
92 kDa
|
| gptkbp:mutationAssociatedWith |
defective checkpoint arrest
sensitivity to DNA damaging agents |
| gptkbp:orthologIn |
gptkb:CHEK2
|
| gptkbp:phosphorylates |
Cdc45
Exo1 Dbf4 Dun1 Mrc1 Pif1 Rad17 Rad24 Rad53 (autophosphorylation) Rad9 Rrm3 Sld3 Sml1 |
| gptkbp:proteinFamily |
kinase domain
FHA domain |
| gptkbp:regulates |
replication stress response
replication fork stability dNTP pool histone gene expression origin firing |
| gptkbp:requires |
viability under DNA damage
|
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:UniProtID |
P25454
|
| gptkbp:bfsParent |
gptkb:CHEK2
|
| gptkbp:bfsLayer |
7
|