|
gptkbp:instanceOf
|
gptkb:disease
genetic disorder
|
|
gptkbp:affects
|
gptkb:women
men
|
|
gptkbp:diagnosedBy
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MRI
genetic testing
biopsy
mammography
|
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gptkbp:hasAssociatedSyndrome
|
gptkb:Li-Fraumeni_syndrome
gptkb:Hereditary_diffuse_gastric_cancer
gptkb:Hereditary_Breast_and_Ovarian_Cancer_syndrome
gptkb:Cowden_syndrome
gptkb:Peutz-Jeghers_syndrome
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hereditary breast cancer
|
|
gptkbp:inheritance
|
autosomal dominant
|
|
gptkbp:mutationAssociatedWith
|
gptkb:CHEK2
gptkb:PALB2
gptkb:PTEN
gptkb:BRCA1
gptkb:BRCA2
gptkb:TP53
ATM
|
|
gptkbp:prevalence
|
5-10% of all breast cancers
|
|
gptkbp:prevention
|
chemoprevention
increased surveillance
prophylactic mastectomy
prophylactic oophorectomy
|
|
gptkbp:riskFactor
|
gptkb:TP53_mutation
gptkb:Li-Fraumeni_syndrome
gptkb:Cowden_syndrome
gptkb:BRCA1_mutation
PTEN mutation
family history of breast cancer
BRCA2 mutation
ATM mutation
CHEK2 mutation
PALB2 mutation
|
|
gptkbp:subspecies
|
gptkb:cancer
|
|
gptkbp:symptom
|
nipple discharge
breast pain
breast lump
skin changes on breast
|
|
gptkbp:treatment
|
surgery
radiation therapy
chemotherapy
hormone therapy
targeted therapy
|
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gptkbp:bfsParent
|
gptkb:BRCM
gptkb:FANCJ
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gptkbp:bfsLayer
|
6
|