Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:ATM_kinase
|
| gptkbp:alternativeName |
Checkpoint kinase 2
|
| gptkbp:associatedWith |
cancer susceptibility
|
| gptkbp:encodedBy |
CHEK2 gene
|
| gptkbp:function |
serine/threonine-protein kinase
|
| https://www.w3.org/2000/01/rdf-schema#label |
CHK2 protein
|
| gptkbp:involvedIn |
DNA damage response
cell cycle checkpoint control |
| gptkbp:locatedOnChromosome |
22q12.1
|
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:molecularWeight |
~62 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:Li-Fraumeni_syndrome prostate cancer |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:phosphorylates |
gptkb:CDC25C
gptkb:BRCA1 gptkb:p53 |
| gptkbp:postTranslationalModification |
phosphorylation
|
| gptkbp:regulates |
apoptosis
cell cycle arrest |
| gptkbp:structure |
contains kinase domain
contains FHA domain |
| gptkbp:UniProtID |
O96017
|
| gptkbp:bfsParent |
gptkb:CHEK2
|
| gptkbp:bfsLayer |
7
|